Redheads require more anesthesia due to variations in the MC1R gene, leading to decreased endorphin levels and increased sensitivity to pain. This article explores the genetics of red hair and anesthesia sensitivity, the challenges that redheads face during medical procedures, and how the medical community is adapting to meet the needs of redheaded patients. It also debunks myths and emphasizes the importance of understanding anesthesia sensitivity to provide safe and effective anesthesia administration.